According to the Environmental Protection Agency, the 2010 Toyota Sienna gets 17 miles per gallon in the city and 23 miles per gallon on the highway when it is coupled with two wheel drive. When the Sienna is coupled with all wheel drive, fuel efficiency drops off slightly. According to the Environmental Protection Agency, the 2010 Toyota Sienna gets 16 miles per gallon in the city and 21 miles per gallon on the highway when it is coupled with all wheel drive.

The engine within the 2010 Toyota Sienna has the same engine that was in the 2009 Sienna. The 2010 Toyota Sienna is the last model in the current generation of Siennas. The 2011 Sienna, which will be the first model in the third generation of the Toyota Sienna, is expected to offer the same 3.5-liter engine. But, for the first time, the Toyota Sienna will offer a four cylinder engine, which will hurt engine performance but will improve fuel efficiency.  costituzione.